Ube2G2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. It has been shown to complex with the E3 ligase called GP78 to catalyze K48 – linked Ub chains. This is an endoplasmic reticulum (ER) associated system to help degrade misfolded ER proteins. Ube2G2 likely interacts with Parkin (an E3 ligase that causes autosomal recessive juvenile Parkinsonism) to ubiquitinate and degrade insoluble Pael receptors.

Additional Information

Product Name: Also Known As: Catalog No.: Size: Molecular Weight: Species: Source: Stock: Concentration: Quality Assurance: Storage: PDF Data Sheet: NCBI RefSeq: Image(s): Shipping Method: References:

6xHis-Ube2G2

UBC7

C2301

100 µg

18.6 kDa

Human

Bacterial recombinant

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol

See tube label

~95% by SDS-PAGE, see datasheet for gel image

Store at -80°C; avoid multiple freeze-thaw cycles

PDF Datasheet， MSDS

NM_003343

(Click image to enlarge)

Coomassie-stained SDS-PAGELane 1: Molecular weight markersLane 2: 5 µg purified 6xHis-Ube2G2

Dry ice shipping

1. Katsanis N, et al. (1998) Genomics 51(1), 128 – 131.2. Imai Y, et al. (2001) Cell 105(7), 891 – 902.3. Arai R, et al. (2006) Acta Crystallogr Sect F Struct Biol Chryst Commun 62(Pt 4), 330 – 334.4. Li W, et al. (2007) Nature 446, 333-7.

Details

Ube2G2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. It has been shown to complex with the E3 ligase called GP78 to catalyze K48 – linked Ub chains. This is an endoplasmic reticulum (ER) associated system to help degrade misfolded ER proteins. Ube2G2 likely interacts with Parkin (an E3 ligase that causes autosomal recessive juvenile Parkinsonism) to ubiquitinate and degrade insoluble Pael receptors. Images:(Click image to enlarge) Coomassie-stained SDS-PAGELane 1: Molecular weight markersLane 2: 5 µg purified 6xHis-Ube2G2