商品介绍
ONX-0914,alsoknownasPR-957,isapotentinhibitoroftheimmunoproteasomewithminimalcross-reactivityfortheconstitutiveproteasome.ONX-0914selectivelyinhibitslow-molecularmasspolypeptide-7(LMP7),thesubunitspecificfortheimmunoproteasomethatcatalyzesthechymotyrpsion-likeactivity,withanIC50<100=""nm.=""cell=""culture=""and=""animal=""studies=""have=""shown=""that=""onx-0914=""blocks=""the=""production=""of=""proinflammatory=""cytokines=""including=""interleukin-6=""and=""17,=""indicating=""that=""it=""has=""potential=""uses=""in=""the=""treatment=""of=""some=""autoimmune=""diseases=""such=""as=""rheumatoid=""arthritis,=""inflammatory=""bowel=""disease=""and=""lupus.="">
Dose:0.1-0.5μMforinvitroorcellcoutureassays;intravenousorsubcutaneousadmiNISTrationat2-10mg/Kgdailyfor5-7daysforanimalstudies.
Dose:0.1-0.5μMforinvitroorcellcoutureassays;intravenousorsubcutaneousadmiNISTrationat2-10mg/Kgdailyfor5-7daysforanimalstudies.
AdditionalInformation
| ProductName: | ONX-0914(PR-957) |
|---|---|
| AlsoKnownAs: | ONX0914;ONX0914;ONX-0914;PR-957;CAS#:960374-59-8 |
| CatalogNo.: | F1410 |
| Size: | 5mg |
| MolecularWeight: | 580.7Da |
| Species: | N/A |
| Source: | Synthetic |
| Stock: | Powder |
| Concentration: | N/A |
| QualityAssurance: | >98%byHPLCandNMR |
| Storage: | EligIBLeforroomtemperatureshipping.Storeat-80°Cuponreceiving;avoidmultiplefreeze-thawcyclesafterdissolvinginDMSO. |
| PDFDataSheet: | PDFDatasheet |
| NCBIRefSeq: | N/A |
| Image(s): | No |
| ShippingMethod: | Roomtemperatureshipping |
| References: | 1.MuchamuelT,etal.(2009)NatMed.15(7):781-7. 2.BaslerM,etal.(2010)JImmunol.185(1):634-41.3.KalimKW,etal.(2012)JImmunol.189(8):4182-93. |
