商品介绍
PS-341isaspecific,reversIBLeandcellpermeabledipeptideboronicacidinhibitorofthechymotrypsin-likeactivityoftheproteasome(Ki=0.6nM).Itinhibitsproliferationofvarioustumorcelllineswithnanomolarpotency.ItscommercialversionwasapprovedbytheUSFDAforthetreatmentofrelapsedmultiplemyeloma.Thetypicalconcentrationsforcellcultureuseare1-20µM.Forinvitrouse,thetypicalconcentrationsare10-100µM.
AdditionalInformation
| ProductName: | PS-341 |
|---|---|
| AlsoKnownAs: | Bortezomib;VELCADE;PS341;MG-341;MG341;Pyz-Phe-boroLeu;CAS#179324-69-7 |
| CatalogNo.: | F1202 |
| Size: | 100mg |
| MolecularWeight: | 384.2Da |
| Species: | N/A |
| Source: | Synthetic |
| Stock: | Powder |
| Concentration: | N/A |
| QualityAssurance: | >98%byHPLCandNMR |
| Storage: | Eligibleforroomtemperatureshipping.Storeat-80°Cuponreceiving;avoidmultiplefreeze-thawcyclesafterdissolvinginDMSO. |
| PDFDataSheet: | DownloadPDFdatasheet |
| NCBIRefSeq: | N/A |
| Image(s): | No |
| ShippingMethod: | Roomtemperatureshipping |
| References: | 1.Yi-HeLingetal.(2002)MolCancerTher,1:841-849. 2.AdamsJ.(2002)TheOncologist,7:9-16. 3.Ling,Y.,etal.(2003).Clin.CancerRes.9,1145-1154. 4.Chauhan,D.,etal.(2005)CancerCell8:407-419. 5.DudekSAetal.(2010)JVirol.84:9439-51. |
