商品介绍
USP16isanactivedeubiquitinatingenzyme(DUB)encodedonchromosome21,trisomyofwhichcausesDown’ssyndrome(DS).USP16isaphosphoprotein,phosphorylationofUSP16controlsitscellularlocalization,butnoeffectonitsDUBactivity.USP16deubiquitinateshistone2A(H2A),throughwhichUSP16mightregulategeneexpressionandcellcycleprogression.IncreasedUSP16proteinlevelsinpeoplewithDSmightcontributetothedevelopmentofcertainphenotypesofDS.
AdditionalInformation
| ProductName: | 6xHis-USP16 |
|---|---|
| AlsoKnownAs: | UBP-M;UBPM |
| CatalogNo.: | H6600 |
| Size: | 25µg |
| MolecularWeight: | 93.5kDa |
| Species: | Human |
| Source: | Insectcell |
| Stock: | 20mMTris,150mMNaCl,2mMβME,10%Glycerol |
| Concentration: | Seetubelabel |
| QualityAssurance: | >90%bySDS-PAGE,seedatasheetforgelimage |
| Storage: | Storeat-80°C;avoidmultiplefreeze-thawcycles |
| PDFDataSheet: | PDFDatasheet，MSDS |
| NCBIRefSeq: | NM_006447.2 |
| Image(s): | H6600image A.DUBactivityassay:15nMUSP16+500nMUb-Rhodamine110.Rhodamine110fluorescencewasmonitoredbyaplatereaderwithexcitation/emissionwavelengthsat480/528nm,respectively. |
| ShippingMethod: | Dryiceshipping |
| References: | 1.JooHY.,etal.(2007)Nature449,1068. 2.AdornoM.,etal.(2013)Nature501,380. |
