商品介绍
Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be conjugated on proteins as monoUb or polyUb chains. Protein ubiquitination plays both proteolytic and nonproteolytic functions. Usually, polyubiquitinated proteins are targeted to the 26S proteasome for proteolysis. Typical concentration to support in vitro ubiquitination is 50-100 µM. In Ub(K33R), lysine 33 was substituted with an arginine, thereby it cannot form lysine 33-linked polyubiquitin chains.
Additional Information
| Product Name: | Ubiquitin (K33R) |
|---|---|
| Also Known As: | UbK33R |
| Catalog No.: | E1660 |
| Size: | 1 mg |
| Molecular Weight: | 8.5 kDa |
| Species: | Human |
| Source: | Bacterial recombinant |
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol |
| Concentration: | See tube label |
| Quality Assurance: | ~95% by SDS-PAGE, see datasheet for gel image |
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| NCBI RefSeq: | N/A |
| Image(s): | No |
| Shipping Method: | Dry ice shipping |
| References: | 1. Hershko A, et al. (1980) Proc Natl Acad Sci USA 77(4), 1783 – 1786. 2. Pickart CM (1997) FASEB 11(13), 1055 – 1066. 3. Hershko A, et al. (1998) Ann Rev Biochem 67, 425 – 479. 4. Jiang X, et al. (2012) Nature Reviews Immunology 12, 35 – 48. 5. Bremm A, et al. (2012) Methods Mol Biol 832, 291 – 228. |
Details
Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be conjugated on proteins as monoUb or polyUb chains. Protein ubiquitination plays both proteolytic and nonproteolytic functions. Usually, polyubiquitinated proteins are targeted to the 26S proteasome for proteolysis. Typical concentration to support in vitro ubiquitination is 50-100 µM. In Ub(K33R), lysine 33 was substituted with an arginine, thereby it cannot form lysine 33-linked polyubiquitin chains.
品牌介绍
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公司介绍
产品分类
E3 Ubiquitin Ligases
Protein Expression / Purification Reagents
Ubiquitin / Ubiquitin-like Proteins / Mutants
E1 Activating Enzymes
Ubiquitin Binding Proteins
Deubiquitinating Enzymes
E2 Conjugating Enzymes
Antibodies
Proteasomes / Activators / Subunits
Ubiquitin / Sumo Chains
Ubiquitin / UBL Derivatives
Fluorescent Peptide / Protein Substrates
Inhibitors
Apoptosis / Necrosis
DNA / Protein Ladders
销售排行
ubpbio/GST-4xSIM/I1300/100 µg
$105.00
ubpbio/TAMRA-Ub26-39(K33)-Ub/M4050/1 mg
$14000.00
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