ubpbio/Human 26S proteasome/A1100/25 µg,UBPBio,,UBPBio,Ubiquitin-Proteasome Biotechnologies,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：ubpbio/Human 26S proteasome/A1100/25 µg

产品编号：A1100

市场价：¥5500.00

场地：美国(厂家直采)

产品分类：蛋白类>酶>蛋白酶类>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$275.00

品牌： UBPBio

公司：Ubiquitin-Proteasome Biotechnologies, LLC

公司分类：

商品介绍

The26Sproteasomeisanapproximately2.5mDalargecomplexcomposedofthe20Sproteasomeandthe19Sregulatoryparticle(alsocalledPA700inmammals).The20Sproteasomehas28subunitsthatformabarrel–shapedstructurearrangedasfourheptomericringofαββα.Threeβsubunitshavepeptidaseactivitiesthathydrolyzeproteins.Eitheroneorbothendsofthe20SproteasomecanassociatewithPA700toformthe26Sproteasome.PA700contains19differentproteinsthathavetheABIlitytobind,deubiquitinateandunfoldpolyubiquitinatedproteinswiththeconsumptionofATPhydrolysis.The26Sproteasomedegradespolyubiquitinatedproteins,whichplaysessentialrolesinregulatingvariouscellulareventsincludingproteinqualitycontrol,genetranscriptionandsignaltransduction.

AdditionalInformation

Details

The26Sproteasomeisanapproximately2.5mDalargecomplexcomposedofthe20Sproteasomeandthe19Sregulatoryparticle(alsocalledPA700inmammals).The20Sproteasomehas28subunitsthatformabarrel–shapedstructurearrangedasfourheptomericringofαββα.Threeβsubunitshavepeptidaseactivitiesthathydrolyzeproteins.Eitheroneorbothendsofthe20SproteasomecanassociatewithPA700toformthe26Sproteasome.PA700contains19differentproteinsthathavetheabilitytobind,deubiquitinateandunfoldpolyubiquitinatedproteinswiththeconsumptionofATPhydrolysis.The26Sproteasomedegradespolyubiquitinatedproteins,whichplaysessentialrolesinregulatingvariouscellulareventsincludingproteinqualitycontrol,genetranscriptionandsignaltransduction.
Images(Clickimagetoenlarge)

ProductName:

Human26Sproteasome

AlsoKnownAs:

26Sproteasome

CatalogNo.:

A1100

Size:

25µg

MolecularWeight:

~3000kDa

Species:

Human

Source:

HEK293

Stock:

20mMTris,pH7.6,40mMNaCl,2mMβME,2mMATP,5mMMgCl₂,10%Glycerol

Concentration:

Seetubelabel

QualityAssurance:

>90%bynative-PAGE

Storage:

Storeat-80°C;avoidmultiplefreeze-thawcycles

PDFDataSheet:

PDFDatasheet，MSDS

NCBIRefSeq:

N/A

Image(s):

(Clickimagetoenlarge)


A.Coomassie-stainedSDS-PAGEof5ugpurifiedhuman26Sproteasome		B.Native-PAGEanalysisof3ugpurifiedhuman26Sproteasome. (1)OverlayassayusingSUC-LLVY-AMCtodeterminethechymotrypsin-likeactivityoftheproteasome.(2)Coomassie-stainednative-PAGEaftertheoverlayassay.

ShippingMethod:

Dryiceshipping

References:

1.WangX,etal.(2007)Biochemistry46,3553-65.


A.Coomassie-stainedSDS-PAGEof5ugpurifiedhuman26Sproteasome					B.Native-PAGEanalysisof3ugpurifiedhuman26Sproteasome. (1)OverlayassayusingSUC-LLVY-AMCtodeterminethechymotrypsin-likeactivityoftheproteasome.(2)Coomassie-stainednative-PAGEaftertheoverlayassay.

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