ABT-263(Navitoclax)isapotentinhibitorofBcl-xL,Bcl-2andBcl-wwithKi~0.5nM,1nMand1nMincell-freeassays.ABT-263blockstheBcl-2/Bcl-xLinteractions,therebypromotingapoptosis.
AdditionalInformation
ProductName: | ABT-263(Navitoclax) |
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AlsoKnownAs: | 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-benzamide |
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CatalogNo.: | F7140 |
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Size: | 5mg |
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CAS: | N/A |
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Formula: | C47H55ClF3O6S3 |
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MolecularWeight: | 974.61Da |
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Form: | Lyophilizedpowder |
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QualityAssurance: | >98%byHPLCandNMR |
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Source: | Synthetic |
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Storage: | EligIBLeforroomtemperatureshipping.Storeat-80°Cuponreceiving |
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PDFDataSheet: | DownloadPDFdatasheet |
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Image(s): | N/A |
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ShippingMethod: | Roomtemperatureshipping |
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References: | TseC,etal.(2008)CancerRes.68(9),3421-3428. |
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Details
ABT-263(Navitoclax)isapotentinhibitorofBcl-xL,Bcl-2andBcl-wwithKi~0.5nM,1nMand1nMincell-freeassays.ABT-263blockstheBcl-2/Bcl-xLinteractions,therebypromotingapoptosis.
Solubility:
>20mg/mlinDMSO
WorkingCondition:
1μMincellcultureassay
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