CHIR-99021(CT99021)isaninhibitorofGSK-3α/βwithIC50of10nM/6.7nM,respectively.CHIR-99021inducestheactivationofglycogensynthase(GS)ininsulinreceptor-expressingCHO-IRcells.
AdditionalInformation
ProductName: | CHIR-99021HCl |
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AlsoKnownAs: | 6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino)ethylamino)nicotinonitrilehydrochloride |
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CatalogNo.: | F6191 |
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Size: | 25mg |
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CAS: | 252917-06-9 |
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Formula: | C22H18Cl2N8.HCl |
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MolecularWeight: | 501.8Da |
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Form: | Lyophilizedpowder |
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QualityAssurance: | >98%byHPLCandNMR |
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Source: | Synthetic |
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Storage: | EligIBLeforroomtemperatureshipping.Storeat-80°Cuponreceiving |
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PDFDataSheet: | DownloadPDFdatasheet |
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Image(s): | N/A |
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ShippingMethod: | Roomtemperatureshipping |
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References: | RingDB,etal.(2003)Diabetes52(3),588-595. |
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Details
CHIR-99021(CT99021)isaninhibitorofGSK-3α/βwithIC50of10nM/6.7nM,respectively.CHIR-99021inducestheactivationofglycogensynthase(GS)ininsulinreceptor-expressingCHO-IRcells.
Solubility:
>20mg/mlinDMSO
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