Apotent,revers
IBLe,cellpermeableandspecificinhibitorofATPaseofp97(alsocalledvalosin-containingprotein(VCP))withIC50of1.5μM.DBeQinhibitsbothubiquitin-dependentandautophagicproteindegradationpathwaysandrapidlyinducescaspases-3and-7activityandapoptosis.
AdditionalInformation
| ProductName: | DBeQ |
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| AlsoKnownAs: | N²,N⁴-Dibenzylquinazoline-2,4-diamine;CAS#177355-84-9;C₂₂H₂₀N₄ |
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| CatalogNo.: | F1420 |
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| Size: | 5mg |
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| MolecularWeight: | 340.42Da |
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| Species: | N/A |
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| Source: | Synthetic |
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| Stock: | Powder |
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| Concentration: | N/A |
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| QualityAssurance: | ≥98%byHPLC |
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| Storage: | Eligibleforroomtemperatureshipping.Storeat-20°Cuponreceiving;protectfromairandlight |
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| PDFDataSheet: | PDFDatasheet |
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| NCBIRefSeq: | N/A |
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| Image(s): | N/A |
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| ShippingMethod: | Roomtemperatureshipping |
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| References: | 1.ChouTF,etal.(2011)ProcNatlAcadSciUSA,108(12),4834-4839.
2.ChouTF,etal.(2011)Autophagy,7(9),1091-1092.
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Details
Apotent,reversible,cellpermeableandspecificinhibitorofATPaseofp97(alsocalledvalosin-containingprotein(VCP))withIC50of1.5μM.DBeQinhibitsbothubiquitin-dependentandautophagicproteindegradationpathwaysandrapidlyinducescaspases-3and-7activityandapoptosis.
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