商品介绍
Deubiquitinatingenzymes(DUBs)areproteasesthatpossestheABIlitytocleaveubiquitinchainsortheisopeptidebondthatconjugatesubiquitinwithasubstrate.Humancellshaveapproximately100DUBsthatplayimportantrolesinregulatingvariouscellularevents.OTUB1isamemberoftheovariantumordomainfamily.ItisrecognizedasaK48ubiquitinchain-specificDUBandcaninhibitE2enzymes,especiallyUbc13(alsoknownasUbe2N),whichisknowntosynthesizeK63-linkedubiquitinchains.OTUB1mayalsodeubiquitinateTRAF3and-6.Thiswouldnegativelyregulatevirus-triggeredtypeIIFNinduction.
AdditionalInformation
| ProductName: | GST-OTUB1 |
|---|---|
| AlsoKnownAs: | OTB1;OTU1;HSPC263 |
| CatalogNo.: | H3011 |
| Size: | 100µg |
| MolecularWeight: | 31.2kDa |
| Species: | Human |
| Source: | Bacterialrecombinant |
| Stock: | 20mMTris,150mMNaCl,2mMβME,10%Glycerol |
| Concentration: | Seetubelabel |
| QualityAssurance: | ~95%bySDS-PAGE,seedatasheetforgelimage |
| Storage: | Storeat-80°C;avoidmultiplefreeze-thawcycles |
| PDFDataSheet: | PDFDatasheet，MSDS |
| NCBIRefSeq: | NM_017670 |
| Image(s): | N/A |
| ShippingMethod: | Dryiceshipping |
| References: | 1.BalakirevMY,etal.(2003)EMBORep4(5),517–522. 2.WangT,etal.(2009)JMolBiol386(4),1011–1023.3.Reyes-TurcuFE,etal.(2009)AnnuRevBiochem78,363–397. 4.LiS,etal.(2010)JBiolChem285(7),4291–4297.5.WienerR,etal.(2012)Nature483(7391),618–622. |
