SUMO(smallUb-relatedmodifier)isaUb-likeprotein.ThreetypesofSUMOaremostcommonlystudied,SUMO1,SUMO2,andSUMO3.SUMO2andSUMO3arealmostidenticalisoformsandthussharemanyfunctions.LikeUb,SUMOcanbeconjugatedtoitstargetproteinsasapolymericchain.However,SUMO1formschainsinefficientlyascomparedtoSUMO2andSUMO3.SUMOisconjugatedtotargetproteinsbytheE1(SAE1/SAE2),E2(Ube2IorUbc9),E3(RanBP2/Nup358,amongstothers).Proteinsumoylationisinvolvedinmanycellularprocessesincludinggenetranscription.
AdditionalInformation
ProductName: | Sumo2 |
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AlsoKnownAs: | HSMT3;SMT3B;SUMO3;Smt3A;SMT3H2;MGC117191 |
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CatalogNo.: | E3200 |
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Size: | 500µg |
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MolecularWeight: | 10.9kDa |
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Species: | Human |
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Source: | Bacterialrecombinant |
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Stock: | 20mMTris,150mMNaCl,2mMβME,10%Glycerol |
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Concentration: | Seetubelabel |
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QualityAssurance: | ~90%bySDS-PAGE,seedatasheetforgelimage |
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Storage: | Storeat-80°C;avoidmultiplefreeze-thawcycles |
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PDFDataSheet: | PDFDatasheet,MSDS |
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NCBIRefSeq: | NM_006937 |
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Image(s): | N/A |
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ShippingMethod: | Dryiceshipping |
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References: | 1.BoddyMN,etal.(1996)Oncogene13,971–982. 2.BayerP,etal.(1998)JMolBiol280,275–286.3.MelchiorF,(2000)AnnuRevCellDevBiol16,591–626. 4.PraefckeGJK,etal.(2012)TrendsBiochemSci37(1),23–31.5.WernerA,etal.(2012)MolCell46(3),287–298.
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Details
SUMO(smallUb-relatedmodifier)isaUb-likeprotein.ThreetypesofSUMOaremostcommonlystudied,SUMO1,SUMO2,andSUMO3.SUMO2andSUMO3arealmostidenticalisoformsandthussharemanyfunctions.LikeUb,SUMOcanbeconjugatedtoitstargetproteinsasapolymericchain.However,SUMO1formschainsinefficientlyascomparedtoSUMO2andSUMO3.SUMOisconjugatedtotargetproteinsbytheE1(SAE1/SAE2),E2(Ube2IorUbc9),E3(RanBP2/Nup358,amongstothers).Proteinsumoylationisinvolvedinmanycellularprocessesincludinggenetranscription.
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