商品介绍
Ub chains are formed by conjugating the C-terminal glycine residue of Ub onto any of seven internal lysine residues or the amino group of the previous Ub. Ub chains are classified by the lysine residue used to link Ubs; different Ub chain topologies can result in different signals. For instance, Ub chains linked through lysine 6, 11, 27, 29, 33 and 48 are capable of targeting proteins for proteasomal degradation; in contrast, Ub chains linked through lysine 63 or the N-terminal amino group (linear Ub chains) often play important nonproteolytic functions including regulation of kinase activation and protein translation. All Ub chain products are produced by using of human wild type Ub reacting with specific E2s.
Additional Information
| Product Name: | K11-Ub(n≥3) |
|---|---|
| Also Known As: | K11-Ub(n≥3) |
| Catalog No.: | D3300 |
| Size: | 25 µg |
| Molecular Weight: | N/A |
| Species: | Human |
| Source: | Bacterial recombinant |
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol |
| Concentration: | See tube label |
| Quality Assurance: | ~95% by SDS-PAGE, see datasheet for gel image |
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| NCBI RefSeq: | N/A |
| Image(s): | N/A |
| Shipping Method: | Dry ice shipping |
| References: | 1. Hershko A, et al. (1980)Proc Natl Acad Sci USA 77(4), 1783 – 1786. 2. Pickart CM, (1997) FASEB 11(13), 1055 – 1066. 3. Hershko A, et al. (1998) Ann Rev Biochem 67, 425 – 479. 4. Jiang X, et al. (2012) Nature Reviews Immunology 12, 35 – 48. |
Details
Ub chains are formed by conjugating the C-terminal glycine residue of Ub onto any of seven internal lysine residues or the amino group of the previous Ub. Ub chains are classified by the lysine residue used to link Ubs; different Ub chain topologies can result in different signals. For instance, Ub chains linked through lysine 6, 11, 27, 29, 33 and 48 are capable of targeting proteins for proteasomal degradation; in contrast, Ub chains linked through lysine 63 or the N-terminal amino group (linear Ub chains) often play important nonproteolytic functions including regulation of kinase activation and protein translation. All Ub chain products are produced by using of human wild type Ub reacting with specific E2s.
品牌介绍
泛素-蛋白酶体生物技术有限公司（UBPBio），LLC是一家私有公司，由科学家和投资人于2011年成立。UBPBio致力于为学术界和工业界提供高质量的试剂，以加快对泛素-蛋白酶体系统及相关途径的发现。 。目前，我们的产品线包括16个类别，提供350多种产品。如果您在泛素领域需要特殊试剂，请与我们联系，我们将竭诚为您服务。
公司介绍
产品分类
E3 Ubiquitin Ligases
Protein Expression / Purification Reagents
Ubiquitin / Ubiquitin-like Proteins / Mutants
E1 Activating Enzymes
Ubiquitin Binding Proteins
Deubiquitinating Enzymes
E2 Conjugating Enzymes
Antibodies
Proteasomes / Activators / Subunits
Ubiquitin / Sumo Chains
Ubiquitin / UBL Derivatives
Fluorescent Peptide / Protein Substrates
Inhibitors
Apoptosis / Necrosis
DNA / Protein Ladders
销售排行
ubpbio/GST-4xSIM/I1300/100 µg
$105.00
ubpbio/TAMRA-Ub26-39(K33)-Ub/M4050/1 mg
$14000.00
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