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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
ubpbio/ITCH/K1400/50 µg
产品编号:K1400
市  场 价:¥4300.00
场      地:美国(厂家直采)
产品分类: 分子类>核酸酶类>连接酶>
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电话号码:4000-520-616
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美  元  价:$215.00
品      牌: UBPBio
公司分类:
ubpbio/ITCH/K1400/50 µg
商品介绍
ITCH,alsocalledatrophin-1interactingprotein4(AIP4),isaHECT-typeE3ubiquitinligase.ItcontainsanN-terminalCa<>-dependentphospholipid-bindingC2domain,fourWWdomains,andaC-terminalHECTdomain.MicedeficientinITCHproteindisplaymanyautoimmune-likediseasecharacteristicssuchaslymphoproliferationinthespleenandlymphnodes.MorethanadozenofsubstratesofITCHhavebeenidentifiedincludingp63,p73andNotch1.TheligasemayberesponsIBLeforubiquitinatingproteinswithK29-,K48-,and/orK63-linkedubiquitinchains.

AdditionalInformation

Details

ITCH,alsocalledatrophin-1interactingprotein4(AIP4),isaHECT-typeE3ubiquitinligase.ItcontainsanN-terminalCa<>-dependentphospholipid-bindingC2domain,fourWWdomains,andaC-terminalHECTdomain.MicedeficientinITCHproteindisplaymanyautoimmune-likediseasecharacteristicssuchaslymphoproliferationinthespleenandlymphnodes.MorethanadozenofsubstratesofITCHhavebeenidentifiedincludingp63,p73andNotch1.TheligasemayberesponsibleforubiquitinatingproteinswithK29-,K48-,and/orK63-linkedubiquitinchains.<>
Images:(Clickimagetoenlarge)
ProductName:ITCH
AlsoKnownAs:AIF4;AIP4;NAPP1;dJ468O1.1
CatalogNo.:K1400
Size:50µg
MolecularWeight:102.8kDa
Species:Human
Source:Bacterialrecombinant
Stock:20mMTris,150mMNaCl,2mMβME,10%Glycerol
Concentration:Seetubelabel
QualityAssurance:~90%bySDS-PAGE,seedatasheetforgelimage
Storage:Storeat-80°C;avoidmultiplefreeze-thawcycles
PDFDataSheet:PDFDatasheetMSDS
NCBIRefSeq:NM_001257137
Image(s):(Clickimagetoenlarge)
Coomassie-stainedSDS-PAGE
Lane1:MolecularweightMarkers
Lane2:5µgpurifiedITCH
ShippingMethod:Dryiceshipping
References:1.PerryWL,etal.(1998)NatGenet18,143–146.
2.SchwarzSE,etal.(1998)JBiolChem273,12148–12154.3.MelinoG,etal.(2008)CellDeathDiffer15(7),1103–1112.
Coomassie-stainedSDS-PAGE
Lane1:Molecularweightmarkers
Lane2:5µgpurifiedITCH
品牌介绍

泛素-蛋白酶体生物技术有限公司(UBPBio),LLC是一家私有公司,由科学家和投资人于2011年成立。UBPBio致力于为学术界和工业界提供高质量的试剂,以加快对泛素-蛋白酶体系统及相关途径的发现。 。目前,我们的产品线包括16个类别,提供350多种产品。如果您在泛素领域需要特殊试剂,请与我们联系,我们将竭诚为您服务。 

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