商品介绍
Ube2T is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2T interacts with the E3 ligase called Fanconi anemia complementation group L (FANCL) that is part of a larger complex to regulate DNA damage repair. Once FANCL interacts with Ube2T, the complex is then able to monoubiquitinate FANCD2 that leads to the DNA repair. Ube2T can also interact with the BRCA1/BARD1 complex.
Additional Information
| Product Name: | 6xHis-Ube2T | ||
|---|---|---|---|
| Also Known As: | PIG50; HSPC150 | ||
| Catalog No.: | C3800 | ||
| Size: | 25 µg | ||
| Molecular Weight: | 22.5 kDa | ||
| Species: | Human | ||
| Source: | Bacterial recombinant | ||
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol | ||
| Concentration: | See tube label | ||
| Quality Assurance: | ~90% by SDS-PAGE, see datasheet for gel image | ||
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles | ||
| PDF Data Sheet: | PDF Datasheet， MSDS | ||
| NCBI RefSeq: | NM_014176 | ||
| Image(s): | (Click image to enlarge)
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| Shipping Method: | Dry ice shipping | ||
| References: | 1. Zhang QH, et al. (2000) Genome Res 10, 1546 – 1560. 2. Machida YJ, et al. (2006) Mol Cell 23, 589-96. 3. Hao J, et al. (2008) Tumour Biol 29, 195 – 203. 4. Ueki T, et al. (2009) Cancer Res 69(22), 8752 – 8760. |
Details
Ube2T is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2T interacts with the E3 ligase called Fanconi anemia complementation group L (FANCL) that is part of a larger complex to regulate DNA damage repair. Once FANCL interacts with Ube2T, the complex is then able to monoubiquitinate FANCD2 that leads to the DNA repair. Ube2T can also interact with the BRCA1/BARD1 complex.
Images: (Click image to enlarge)
Images: (Click image to enlarge)
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Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified 6xHis-Ube2T |
品牌介绍
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公司介绍
产品分类
E3 Ubiquitin Ligases
Protein Expression / Purification Reagents
Ubiquitin / Ubiquitin-like Proteins / Mutants
E1 Activating Enzymes
Ubiquitin Binding Proteins
Deubiquitinating Enzymes
E2 Conjugating Enzymes
Antibodies
Proteasomes / Activators / Subunits
Ubiquitin / Sumo Chains
Ubiquitin / UBL Derivatives
Fluorescent Peptide / Protein Substrates
Inhibitors
Apoptosis / Necrosis
DNA / Protein Ladders
销售排行
ubpbio/GST-4xSIM/I1300/100 µg
$105.00
ubpbio/TAMRA-Ub26-39(K33)-Ub/M4050/1 mg
$14000.00
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