ubpbio/6xHis-PA28beta/A2201/100 µg,UBPBio,,UBPBio,Ubiquitin-Proteasome Biotechnologies,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：ubpbio/6xHis-PA28beta/A2201/100 µg

产品编号：A2201

市场价：¥3800.00

场地：美国(厂家直采)

产品分类：蛋白类>酶>蛋白酶类>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$190.00

品牌： UBPBio

公司：Ubiquitin-Proteasome Biotechnologies, LLC

公司分类：

商品介绍

PA28(alsocalledthe11Sregulatorycomplex)isanotheractivatorofthe20Sproteasome,whichassemblesoneitheroneorbothendsofthe20SproteasomeinanATP-independentmanner.PA28cangreatlyenhancethepeptidaseactivitiesofthe20Sproteasome,butnotfordegradationofubiquitinatedproteins.ThePA28activatorisacomplexoftwoalternatinghomologoussubunits,PA28αandPA28β,whichassemblesasahexamericringwithanα3β3stoichiometry.PA28αandPA28βareinducedbyinterferon.Functionally,PA28enhancesthegenerationofclassIpeptidesforantigenpresentation.Thethirdsubunit,PA28γ,wasrecentlyidentifiedinthenucleus.RecombinantPA28αandPA28βformaheptomericring;whereasPA28γformsahexamericring.Allofthemcanstimulatethepeptidaseactivitiesofthe20Sproteasome.

AdditionalInformation

Details

ProductName:

6xHis-PA28beta

AlsoKnownAs:

PSME2;PA28B;REGbeta;PA28beta;PA28-beta;PA28beta

CatalogNo.:

A2201

Size:

100µg

MolecularWeight:

27.4kDa

Species:

Human

Source:

Bacterialrecombinant

Stock:

20mMTris,150mMNaCl,2mMβME,10%Glycerol

Concentration:

Seetubelabel

QualityAssurance:

~95%bySDS-PAGE,seedatasheetforgelimage

Storage:

Storeat-80°C;avoidmultiplefreeze-thawcycles

PDFDataSheet:

PDFDatasheet，MSDS

NCBIRefSeq:

NM_002818

Image(s):

(Clickimagetoenlarge)

Coomassie-stainedSDS-PAGE
Lane1:MolecularweightMarkersLane2:5µgpurified6xHis-PA28beta

Activationof5nM20Sproteasome(Cat.#A1400)by25nMPA28β(Cat.#A2200),theproteasomeactivitywasassayedbyusing50µMSuc-LLVY-AMC(Cat.#G1100)asthesubstrate.TheAMCfluorescencewasmonitoredbyaplatereaderwithexcitationandemissionfiltersof360±40nmand460±30nm,respectively.

ShippingMethod:

Dryiceshipping

References:

1.MaCP,etal.(1992)JBiolChem267(15),10515–10523.
2.WhitbyFG,etal.(2000)Nature408(6808),115–120.3.CascioP,etal.(2002)TheEMOJournal21,2636–2645.
4.SijtsEJAM,etal.(2011)CellMolLifeSci68(9),1491–1502.

Coomassie-stainedSDS-PAGE
Lane1:MolecularweightmarkersLane2:5µgpurified6xHis-PA28beta

品牌介绍

泛素-蛋白酶体生物技术有限公司（UBPBio），LLC是一家私有公司，由科学家和投资人于2011年成立。UBPBio致力于为学术界和工业界提供高质量的试剂，以加快对泛素-蛋白酶体系统及相关途径的发现。。目前，我们的产品线包括16个类别，提供350多种产品。如果您在泛素领域需要特殊试剂，请与我们联系，我们将竭诚为您服务。

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